Angiotensin-converting enzyme (ACE) gene polymorphisms and familial occurrence of sarcoidosis

Angiotensin Converting Enzyme in Sarcoidosis

angiotensin converting enzyme in sarcoidosis

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polymorphism in the angiotensin-converting enzyme (ace) gene and ace activity in type 2 diabetic patients

diabetes mellitus is a multifactorial disease. it has recently been shown that an insertion (i)/deletion (d) polymorphism exists in the angiotensin-converting enzyme (ace) gene that can affect the serum ace level. there are three genotypes: dd, di, and ii, with the ace level being highest in dd, intermediate in di, and lowest in ii. in the present investigation, 170 patients with type 2 diabete...

Proteinuria and angiotensin converting enzyme (ACE) gene polymorphism.

INTRODUCTION Although proteinuria is traditionally regarded as the result of glomerular damage, recent evidence suggests that proteinuria can directly cause renal damage through lysosomal injury, growth factor induced tubular fibrosis and transcriptase genes which trigger vasoactive and inflammatory renal damage. The renin angiotensin system which releases angiotensin, a most powerful vasoconst...

Extreme elevation of serum angiotensin-converting enzyme (ACE) activity: always consider familial ACE hyperactivity.

Measurement of serum angiotensin-converting enzyme (ACE) activity can be helpful in the diagnosis and disease monitoring of sarcoidosis. Elevated serum ACE activity is found in 60-70% of sarcoidosis patients. Usually, the ACE activity is mildly increased (<3-fold the upper limit of the reference range) in sarcoidosis patients. Extremely elevated ACE activity is suggestive of the benign conditio...